Received: 24 May 2019
Accepted: 1 August 2019
First Online: 9 August 2019
Ethics approval and consent to participate
: The authorization to use animals were obtained by the Italian Health Authority. The Care and Husbandry of animals are in accordance with European Directives no. 86/609 and with the Italian Regulatory system (D.L. vo no. 26/14). All methods were carried out in accordance with relevant guidelines and regulations and all experimental protocols were approved by the Italian Ministry of Health. All efforts were made to minimize animal suffering and to reduce the number of animals used.
: The authors declare that they have no competing interests.