Funding for this research was provided by:
Ministero della Salute (Progetto Finalizzata-PE 2013-02354871)
Received: 11 November 2019
Accepted: 14 February 2020
First Online: 22 February 2020
Ethics approval and consent to participate
: The study protocol for the collection and use of the bone marrow sample was approved by the Ethics Committee of the Rizzoli Orthopaedic Institute (Approval n. 0003044/2016). Patients involved in the study provided a signed informed consent before the collection of bone marrow samples. All animal studies were performed in accordance with the guidelines of the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals, following protocols approved by the Institutional Animal Care and Use Committee (IACUC, protocol AUP-0118-0002) at the Houston Methodist Research Institute.
: Not applicable.
: We declare that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere. We wish to confirm that there are no conflicts of interest associated with this publication and there have been no competing financial interests for this work that could have influenced its outcome. We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship that are not listed. We further confirm that all of us have approved the order of authors listed in the manuscript. We confirm that we have given due consideration to the protection of intellectual property associated with this work and that are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property.