Vitiello, Pietro Paolo
Martini, Giulia
Mele, Luigi
Giunta, Emilio Francesco
De Falco, Vincenzo
Ciardiello, Davide
Belli, Valentina
Cardone, Claudia
Matrone, Nunzia
Poliero, Luca
Tirino, Virginia
Napolitano, Stefania
Della Corte, Carminia
Selvaggi, Francesco
Papaccio, Gianpaolo
Troiani, Teresa
Morgillo, Floriana
Desiderio, Vincenzo
Ciardiello, Fortunato
Martinelli, Erika
Funding for this research was provided by:
Associazione Italiana per la Ricerca sul Cancro (MFAG-2015-ID:7778, IG-2013-ID:14800)
Regione Campania (I-CURE)
Article History
Received: 12 September 2020
Accepted: 11 December 2020
First Online: 6 January 2021
Ethics approval and consent to participate
: Patient-derived specimens for the establishment of primary cultures were obtained from patients enrolled in the I-CURE project (Regione Campania). The protocol was approved by the Università degli Studi della Campania L. Vanvitelli Ethics Committee, and every patient provided and signed and informed consent for tissue processing, storage and molecular characterization.The research protocol for animal experiments was approved and mice were maintained in accordance with the institutional guidelines of the Università degli Studi della Campania L. Vanvitelli Animal Care and Use Committee. Animal care was mantained in compliance with Italian (Decree 116/92) and European Community (E.C. L358/1 18/12/86) guidelines on the use and protection of laboratory animals. Mice were acclimatized at Università degli Studi della Campania L. Vanvitelli Medical School Animal Facility for 1 week prior to being injected with cancer cells and then caged in groups of no more than five mice.
: Not applicable.
: EM: advisory board for Amgen, Bayer, Merck, Roche, Sanofi, Servier, Biocartis and expert opinion for ESMO (European Society of Medical Oncology). TT: advisory board for Amgen, Bayer, Merck, Novartis, Roche, Sanofi. FM: advisory board for Lilly, MSD. FC: advisory board for Merck, Roche, Amgen, Bayer, Servier, Symphogen,Pfizer and research funding from Roche, Merck, Amgen, Bayer, Ipsen. All other Authors declare no potential conflicts of interest regarding the following manuscript.