Funding for this research was provided by:
Instituto Nacional de Genética Médica Populacional
Conselho Nacional de Desenvolvimento Científico e Tecnológico (307986/2015-2)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.302898/2018-00)
Received: 3 January 2019
Accepted: 5 May 2019
First Online: 14 May 2019
Ethics approval and consent to participate
: This study was approved by the institutional ethics committee of Hospital de Clínicas de Porto Alegre, Brazil which is recognized by the Office for Human Research Protections as an Institutional Review Board (IRB0000921). All patients provided written informed consent (protocol number 2003–0066).
: Not applicable.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.