Funding for this research was provided by:
Agentschap voor Innovatie door Wetenschap en Technologie (IWT-TBM110685)
Fonds Wetenschappelijk Onderzoek (METH/08/07, METH/14/06)
FP7 Ideas: European Research Council (321670)
Erasmus Medisch Centrum (Cost-Effectiveness Research Grant)
Vereniging Trustfonds Erasmus Universiteit Rotterdam
Anonymous Dutch family (private donation)
Received: 18 August 2017
Accepted: 27 December 2017
First Online: 15 January 2018
Ethics approval and consent to participate
: The institutional ethical review boards of the participating centres in Leuven (ML8052), Rotterdam (NL38772.000.12) and Edmonton (Pro00038098) approved the study, which was performed in accordance with the 1964 Declaration of Helsinki and its amendments. Written informed consent was obtained from the parents or legal guardians.
: Not applicable.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.