Spoelstra-de Man, Angelique M. E.
Elbers, Paul W. G.
Oudemans-van Straaten, Heleen M.
Article History
First Online: 20 March 2018
Ethics approval and consent to participate
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: Research grant from ZonMW, the Netherlands Health Organization for Health Research and Development, to perform a randomized controlled trial on high dose vitamin C after cardiac arrest. No financial conflicts of interest.
: The caption for Fig 3 should read as follows: Pleiotropic effects of vitamin C. 1. Vitamin C scavenges free radicals from superoxide (O2∙-). 2. Vitamin C inhibits activation of xanthine oxidase and of 3, NADPH oxidase. 4. Vitamin C protects the mitochondria from oxidative stress caused by increased leakage of electrons from the dysfunctional electron transport chain. 5. Vitamin C recovers tetrahydrobiopterin (BH4) from dihydrobiopterin (BH2), restoring endothelial nitric oxide synthase (eNOS) activity and increasing eNO bioavailability. 6. Vitamin C inhibits inducible NOS (iNOS) activation, preventing profuse iNO production and peroxynitrite (ONOO−) generation. 7. Vitamin C scavenges ONOO−, preventing loosening of the tight junctions of the endothelium. 8. Vitamin C recovers α‐tocopherol, which protects against lipid peroxidation.
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