Hollen, McKenzie K.
Stortz, Julie A.
Darden, Dijoia
Dirain, Marvin L.
Nacionales, Dina C.
Hawkins, Russell B.
Cox, Michael C.
Lopez, Maria-Cecilia
Rincon, Jaimar C.
Ungaro, Ricardo
Wang, Zhongkai
Wu, Quran
Brumback, Babette
Gauthier, Marie-Pierre L.
Kladde, Michael
Leeuwenburgh, Christiaan
Segal, Mark
Bihorac, Azra
Brakenridge, Scott
Moore, Frederick A.
Baker, Henry V.
Mohr, Alicia M.
Moldawer, Lyle L.
Efron, Philip A.
Funding for this research was provided by:
National Institute of General Medical Sciences (R01 GM-040586, R01 GM-104481, R01 GM-113945, P50 GM-111152, T32 GM-008721, T32 GM-008721, T32 GM-008721)
Article History
Received: 25 July 2019
Accepted: 27 September 2019
First Online: 13 November 2019
Ethics approval and consent to participate
: This prospective observational cohort study was approved by the Institutional Review Board of the University of Florida (UF) and was performed from 2015 to 2019 at UF Health Shands Hospital, a 996-bed academic quaternary-care referral center. The study was registered withExternalRef removed(NCT02276417) and conducted by the Sepsis and Critical Illness Research Center at UF, whose study design and protocols have been previously published [CitationRef removed]. All patients eligible for inclusion in the study were enrolled within 12 h of sepsis protocol onset on a delayed waiver of consent, which was approved by our Institutional Review Board. If written informed consent could not be obtained from the patient or their legally assigned representative within 96 h of study enrollment, the patient was removed from the study and all collected biologic samples and clinical data were destroyed.
: Not applicable
: The authors declare that they have no competing interests.