Clinical trials referenced in this document:
Received: 2 September 2020
Accepted: 1 January 2021
First Online: 12 January 2021
Ethics approval and consent to participate
: In unresponsive patients, informed consent was first obtained from the legal representatives. Consent for the use of the study data was asked at a later time if the patient recovered consciousness. If the patient died before consent was obtained, the study data was used, and the legal representatives were informed of the study. The local institutional review board (METc Groningen) approved both cohort studies (2015/004 and 2018/203) and the current analysis (2019/078).
: Not applicable.
: KM reports grants from Bayer, Sanquin, and Pfizer; speaker fees from Bayer, Sanquin, Boehringer Ingelheim, BMS, and Aspen; travel support from Bayer, and consulting fees from Uniqure outside the submitted work; other authors have disclosed no potential conflicts of interest.