Fenn, Dominic
Abdel-Aziz, Mahmoud I.
van Oort, Pouline M. P.
Brinkman, Paul
Ahmed, Waqar M.
Felton, Timothy
Artigas, Antonio
Póvoa, Pedro
Martin-Loeches, Ignacio
Schultz, Marcus J.
Dark, Paul
Fowler, Stephen J.
Bos, Lieuwe D. J.
Ahmed, Waqar M.
Raventos, Antonio Artigas
Bannard-Smith, Jonathan
Bos, Lieuwe D. J.
Camprubi, Marta
Coelho, Luis
Dark, Paul
Davie, Alan
Diaz, Emili
Goma, Gemma
Felton, Timothy
Fowler, Stephen J.
Goodacre, Royston
Johnson, Craig
Knobel, Hugo
Lawal, Oluwasola
Leopold, Jan-Hendrik
Martin-Loeches, Ignacio
Nijsen, Tamara M. E.
van Oort, Pouline M. P.
Povoa, Pedro
Rattray, Nicholas J. W.
Rijnders, Guus
Schultz, Marcus J.
Steenwelle, Ruud
Sterk, Peter J.
Valles, Jordi
Verhoeckx, Fred
Vink, Anton
Weda, Hans
White, Iain R.
Winters, Tineke
Zakharkina, Tetyana
,
Funding for this research was provided by:
NIHR Manchester Biochemical Research Centre
FP7 People: Marie-Curie Actions (MC-IAPP BreathDx 611951, MC-IAPP BreathDx 611951)
Article History
Received: 14 February 2022
Accepted: 22 June 2022
First Online: 6 July 2022
Declarations
:
: The patient information letters, informed consent forms and the study protocol were approved by the institutional review boards (IRBs) of the individual institutions: IRB of the Academic Medical Centre Amsterdam, and for the three UK-based centres, by the National Research Ethics Service Committee North West—Greater Manchester South (REC reference 15/NW/0393) and the local Research and Development (R&D) offices at the different sites. Since this study concerned the inclusion of patients lacking capacity, formal assent was sought at time of inclusion from a designated consultee who was independent of the study. For patients that regained capacity, deferred written consent was obtained. If patients did not regain capacity, the General Data Protection Regulation (GDPR) states that the obtained data could be used for research purposes without consent. BreathDx was registered by the UK Clinical Research Network (ID no. 19086). The study methods have previously been published [CitationRef removed].
: Not applicable.
: Dr Dominic Fenn has nothing to disclose. Dr Abdel-Aziz has nothing to disclose. Dr Pouline M. P. van Oort has nothing to disclose. Dr Paul Brinkman has nothing to disclose. Dr Waqar M. Ahmed has nothing to disclose. Dr Timothy Felton has nothing to disclose. Dr Antonio Artigas reports grants, personal fees and other from Grifols, grants from Fisher and Paykel, personal fees and other from Aerogen, other from Novartis, outside the submitted work. Dr Pedro Póvoa reports personal fees from MSD, personal fees from Gilead, outside the submitted work. Dr Ignacio Martin-Loeches has nothing to disclose. Dr Marcus J. Schultz has nothing to disclose. Dr Paul Dark has nothing to disclose. Dr Stephen J. Fowler has nothing to disclose. Dr Lieuwe D.J. Bos reports grants from the Dutch lung foundation (Young investigator grant), grants from the Dutch lung foundation and Health Holland (Public–Private Partnership grant), grants from the Dutch lung foundation (Dirkje Postma Award), grants from IMI COVID-19 initiative, grants from Amsterdam UMC fellowship, outside the submitted work. On behalf of the authors, I can confirm that there is no conflict of interest and that the manuscript has not been published elsewhere or under consideration by another journal. All the authors have approved the manuscript and agree with its submission to Critical Care.