Schöffski, Patrick
Cresta, Sara
Mayer, Ingrid A.
Wildiers, Hans
Damian, Silvia
Gendreau, Steven
Rooney, Isabelle
Morrissey, Kari M.
Spoerke, Jill M.
Ng, Vivian W.
Singel, Stina M.
Winer, Eric
Funding for this research was provided by:
Genentech Inc. / F.Hoffmann-La Roche Ltd.
Article History
Received: 15 September 2017
Accepted: 3 July 2018
First Online: 5 September 2018
Ethics approval and consent to participate
: This study was conducted in accordance with good clinical practice guidelines and the Declaration of Helsinki. Approval of the protocol and any accompanying material provided to the patients was obtained from independent ethics committees at participating institutions (InternalRef removed InternalRef removed). All patients provided written informed consent.
: Not applicable.
: PS has received travel support from Roche for presentation of parts of this work at the 37th San Antonio Breast Cancer Symposium in 2014, institutional research support from Genentech for exploring pictilisib in patient-derived xenograft models of sarcoma, and institutional technical support from Roche (donation of a LightCycler). In addition, and outside the submitted work, PS has received honoraria (institutional support) from Daiichi Sankyo, Eisai, Eli Lilly, Medpace, Novartis, and Swedish Orphan Biovitrium; consulting or advisory role institutional support from Sixth Element Capital, Adaptimmune, Amcure, AstraZeneca, Bayer, Blueprint Medicines, BMS, Boehringer Ingelheim, Cristal Therapeutics, Daiichi Sankyo, Eisai, Eli Lilly, Epizyme, Genzyme, Ipsen, Loxo Oncology, Medpace, Nektar, Novartis, Philogen, PIQUR Therapeutics, and Plexxikon; speaker’s bureau institutional support from Bayer, Eisai, Eli Lilly, GSK, Novartis, PharmaMar, and Swedish Orphan Biovitrium; research funding (institutional support) from Bayer, Blueprint Medicines, CoBioRes NV, Exelixis, GSK, Novartis, and Plexxikon; and institutional support for travel, accommodation, and expenses from Sixth Element Capital, Adaptimmune, Amcure, AstraZeneca, Bayer, Blueprint Medicines, BMS, Boehringer Ingelheim, Cristal Therapeutics, Daiichi Sankyo, Eisai, Eli Lilly, Epizyme, Genzyme, GSK, Ipsen, Loxo Oncology, Medpace, Nektar, Novartis, PharmaMar, Philogen, PIQUR Therapeutics, Plexxikon, and Swedish Orphan Biovitrium. IAM has received research support from Novartis and Pfizer and advisory board honoraria from Novartis. HW has received advisory board honoraria, speaker‘s fees, and travel support from Roche. SG, IR, KMM, JMS, VWN, and SMS are employees of Genentech/Roche. EW has received research support from Genentech, an advisory board honorarium from Genentech, and scientific advisory board support from Leap Pharmaceuticals. SC and SD declare that they have no potential conflicts of interest.
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