Funding for this research was provided by:
National Natural Science Foundation of China (31720103909,31671368 and 31771299)
National Key R&D Project of China (2018YFE0201600, 2018YFA0801100,2017YFC0907502, 2017YFC0907000, 2017YFF0204600, and 2016YFC0901704)
Shanghai Municipal Science and Technology Major Project (2017SHZDZX01)
Chinese Academy of Sciences’ Major R&D Project (XDA12040104)
Shandong Province Key R&D Project (2017CXGC1209)
the 111 Project (B13016)
Received: 18 September 2020
Accepted: 13 April 2021
First Online: 1 May 2021
: This study was approved by the independent ethics committee at Fudan University Shanghai Cancer Center. The patient and all participating family members provided written informed consent to participate in the study.
: Not applicable.
: The authors declare that they have no competing interests.