Collin, Lindsay J. http://orcid.org/0000-0003-0170-2592
Maliniak, Maret L.
Cronin-Fenton, Deirdre P.
Ahern, Thomas P.
Christensen, Kristina B.
Ulrichsen, Sinna P.
Damkier, Per
Hamilton-Dutoit, Stephen
Yacoub, Rami
Christiansen, Peer M.
Sørensen, Henrik Toft
Lash, Timothy L.
Funding for this research was provided by:
National Cancer Institute (R21CA185932, R01CA118708, R01CA166825, F31CA239566)
Kræftens Bekæmpelse (DP06117)
Lundbeckfonden (R167-2013-15861)
Sundhed og Sygdom, Det Frie Forskningsråd (DOK 1158869)
National Center for Advancing Translational Sciences (TL1TR002540)
Article History
Received: 26 April 2021
Accepted: 23 October 2021
First Online: 4 November 2021
Declarations
:
: The study was approved by the Danish Data Protection Agency, the Danish Ethical Committee, and the Emory University Institutional Review Board.
: Not applicable.
: The authors have no conflict of interest to declare.
: Hypoxia-inducible factor-1α (HIF-1α) facilitates adaption of cancer cells to hypoxic tumor microenvironments and may be prognostic of breast cancer recurrence. In this study, we evaluated the association of HIF-1α expression with breast cancer recurrence and timing of recurrence in a population-based case–control study. We observed a near-null association between HIF-1α expression and breast cancer recurrence overall, and that HIF-1α expression may be associated with early recurrence among women diagnosed with estrogen receptor negative breast cancer.