Received: 9 August 2019
Accepted: 28 November 2019
First Online: 31 December 2019
Ethics approval and consent to participate
: Tissue samples were obtained from the Cambridge Biorepository for Translational Medicine (CBTM [CitationRef removed];) with informed consent from the donor families and approval from the NRES Committee of East of England—Cambridge South (15/EE/0152). This consent includes generation of open-access genetic sequencing data and publication in open access journals in line with Wellcome Trust policy. CBTM operates in accordance with UK Human Tissue Authority guidelines (HTA [CitationRef removed];). All experimental methods comply with the Helsinki Declaration.
: All samples were provided as linked-anonymized, with the linkage key held by the clinician. Consent was obtained as part of the Research Ethics Committee (REC) approval.
: MJTS has been employed by 10x Genomics since April 2018; this employment had no bearing on this work. RJM has been employed by MedImmune/AstraZeneca since October 2018; this employment had no bearing on this work. The other authors declare that they have no competing interests.