Funding for this research was provided by:
Fundación Científica Asociación Española Contra el Cáncer (GC16173697BIGA)
Received: 29 May 2020
Accepted: 3 November 2020
First Online: 23 November 2020
Ethics approval and consent to participate
: All patients were included in protocols (LAL-07OLD, ALL-HR-03, LAL-AR-2011) from the PETHEMA group, except PAT16. These protocols were approved by the Institutional Research Board (IRB) of the participating centers and patients provided informed consent before entering into the trials. The study was approved by the Comitè d’Ètica de la Investigació (Research Ethics Committee: PI-16-146) of the Hospital Germans Trias y Pujol (code approval AEC143). The study complies fully with the Helsinki declaration.
: The authors declare that they have no competing interests.