Funding for this research was provided by:
Biotechnology and Biological Sciences Research Council (BB/R012504/1, BBS/E/F/000PR10351, BB/P013759/1, BB/P013732/1, BB/J004235/1, BB/J004243/1)
Medical Research Council (MR/L015080/1)
Text and Data Mining valid from 2020-02-12
Received: 22 July 2019
Accepted: 27 January 2020
First Online: 12 February 2020
Ethics approval and consent to participate
: Animals were housed in premises licensed under a UK Home Office Establishment License within the terms of the UK Home Office Animals (Scientific Procedures) Act 1986. Housing and husbandry complied with the Code of Practice for Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes and were overseen by the Roslin Institute Animal Welfare and Ethical Review Board. Animals were culled by schedule one methods authorised by the Animals (Scientific Procedures) Act 1986.
: Not applicable
: The authors declare that they have no competing interests.