Funding for this research was provided by:
National Heart, Lung, and Blood Institute (HHSN268201300002I/N01-HC-65235, R01-HL140976)
National Heart, Lung, and Blood Institute (R01-HL060712)
Received: 15 February 2021
Accepted: 23 November 2021
First Online: 10 December 2021
: All participants enrolled in the HCHS/SOL completed informed consent at the time of enrollment into the cohort and subsequently provided informed consent to participate in the gut microbiome ancillary study project. IRBs of all participating institutions approved the study. The IRB of the lead institution (Albert Einstein College of Medicine) has approved the HCHS/SOL project under reference number 2007-432. The National Institutes of Health maintains an Observational Study Monitoring Board which reviews the project, participant safety, and burden. All experimental methods comply with the Helsinki Declaration.
: All participants provided written informed consent for collection, analysis, and publication of their study data and results of laboratory tests derived from their biospecimens. The manuscript was reviewed by the HCHS/SOL Publications Committee which provided its approval for submission of this work for publication
: The authors declare that they have no competing interests.