Jain, Mika Sarkin
Polanski, Krzysztof
Conde, Cecilia Dominguez
Chen, Xi
Park, Jongeun
Mamanova, Lira
Knights, Andrew
Botting, Rachel A.
Stephenson, Emily
Haniffa, Muzlifah
Lamacraft, Austen
Efremova, Mirjana http://orcid.org/0000-0002-8107-9974
Teichmann, Sarah A.
Funding for this research was provided by:
Gates Cambridge Scholarship
Barts Charity (MGU045)
Wellcome Trust (WT206194, WT211276/Z/18/Z)
Chan Zuckerberg Initiative (CZF2019-002445)
Article History
Received: 26 August 2021
Accepted: 3 December 2021
First Online: 20 December 2021
Declarations
:
: The thymus tissue sample used for this study was obtained with written informed consent from the participant in accordance with the guidelines in The Declaration of Helsinki 2000. The human fetal tissue was obtained from the MRC/Wellcome Trust-funded Human Developmental Biology Resource (HDBR, ExternalRef removed) with appropriate maternal written consent and approval from the Newcastle and North Tyneside NHS Health Authority Joint Ethics Committee (08/H0906/21 + 5). HDBR is regulated by the UK Human Tissue Authority (HTA; ExternalRef removed) and operates in accordance with the relevant HTA Codes of Practice.The mice for the splenocyte data were maintained under specific pathogen-free conditions at the Wellcome Trust Genome Campus Research Support Facility (Cambridge, UK). These animal facilities are approved by and registered with the UK Home Office. All procedures were in accordance with the Animals (Scientific Procedures) Act 1986. The protocols were approved by the Animal Welfare and Ethical Review Body of the Wellcome Trust Genome Campus.
: S.A.T. has received remunerations for consulting and Scientific Advisory Board work from Genentech, Biogen, Roche, and GlaxoSmithKline as well as Foresite Labs over the past 3 years.