Funding for this research was provided by:
National Institute for Health Research Health Technology Assessment Programme (12/35/23)
Received: 24 February 2017
Accepted: 4 December 2017
First Online: 24 January 2018
Ethics approval and consent to participate
: The study was centrally approved by the North of Scotland Research Ethics Service (Reference no. 13/NS/0155) for all 33 UK centres and will be conducted according to the principles of Good Clinical Practice provided by Research Governance Guidelines. Annual progress reports and a final report at the conclusion of the trial will be submitted to North of Scotland Research Ethics Committee 2 within the timelines defined in the regulations. Women must provide signed and dated written informed consent before undergoing any study-specific procedures.A completed SPIRIT Checklist is shown in Additional file InternalRef removed [CitationRef removed].
: Not applicable.
: The authors declare that they have no competing interests.
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