Funding for this research was provided by:
Horizon 2020 (634886)
Received: 15 June 2017
Accepted: 7 December 2017
First Online: 25 January 2018
Ethics approval and consent to participate
: The study is carried out in compliance with the recommendations of the Declaration of Helsinki [CitationRef removed], GCP and in accordance with local guidelines, regulations, and acts. The medical ethical committee of all participating countries approved the trial (the names of the ethical bodies are provided in Additional file InternalRef removed). Patients give informed consent before they are randomised in the study.
: The manuscript does not contain individual data.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.