Funding for this research was provided by:
National Institute for Health Research (PB-PG-0815-20029)
Intensive Care Society
Received: 30 January 2019
Accepted: 29 June 2019
First Online: 24 July 2019
Ethics approval and consent to participate
: The study was reviewed and approved by London Queens Square Ethics Committee (ref. 17/LO/0934) in September 2017. All subsequent substantial amendments to the protocol have been reviewed and approved by the ethics committee and Health Research Authority (HRA) and all non-substantial amendments were notified to the HRA. The trial has been registered in the ISRCTN Registry (trial ID: ISRCTN44340629) and is conducted in compliance with Good Clinical Practice standards and principles of the Declaration of Helsinki (2013).Written prospective or retrospective informed consent will be obtained from all participants.
: By giving written informed consent, participants have provided their permission for storage of data and publication of the study results. All authors consent to publication.
: The authors declare that they have no competing interests.