Funding for this research was provided by:
JSPS KAKENHI (JP17H04122)
Text and Data Mining valid from 2019-12-01
Received: 26 May 2019
Accepted: 25 October 2019
First Online: 11 December 2019
Ethics approval and consent to participate
: All researchers participating in the trial will abide by the Declaration of Helsinki and its amendments, as well as the Ethical guidelines for medical and health research involving human subjects (2017 revision, Ministry of Education, Culture, Sports, Science and Technology, and MHLW). The trial has been approved by the Ethics Committee of the Kyoto University Graduate School of Medicine (registration number: C1401) and the Institutional Review Boards of Toyooka Hospital (registration number: 180).
: Not applicable.
: TS received a stipend from Pfizer, Inc.ST has received lecture fees from Boehringer Ingelheim, Astra-Zeneca, Taiho Pharmaceutical, Ono Pharmaceutical, and JMDC Inc. He received consultation fees from the Pharmaceuticals and Medical Devices Agency and DeNA Life Science and outsourcing fees from the Public Health Research Foundation. ST has received grants from the Japan Agency for Medical Research and Development, the Japanese Ministry of Health, Labor and Welfare, and the Japanese Ministry of Education, Culture, Sports, Science and Technology. He engaged in a research project of the Japan Agency for Medical Research and Development.KK received honoraria from Shin Nippon Biomedical Laboratories, Ltd.; research funds from Olympus Corporation, Sumitomo Dainippon Pharma Co., Ltd., Bayer Yakuhin Ltd., Stella.Pharma Corporation, Novartis Pharma K.K., CMIC Co., Ltd., Amgen Astellas BioPharma K.K., Suntory Beverage & Food Ltd., and Medical Platform Co., Ltd.; and holds stocks in School Health Record Center Co., Ltd. and Real World Data, Co., Ltd. There are no patent products under development or marketed products to declare that are relevant to those companies.TAF has received lecture fees from Janssen, Meiji, Mitsubishi-Tanabe, MSD,and Pfizer. TAF has received research support from Mitsubishi-Tanabe and Mochida.All other authors report that they have no relationships to disclose that are relevant to the contents of this paper.