Received: 11 January 2020
Accepted: 16 May 2020
First Online: 3 June 2020
Ethics approval and consent to participate
: This study protocol was approved by the Nagasaki University Hospital Clinical Research Ethics Committee (authorization number: 19102101) prior to participant recruitment, and registered with the University Hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR; No. UMIN000038072) on 21 September 2019. Informed consent will be obtained from all study participants. The modified study protocol will not be performed without REC approval. The results of this study will be disseminated to the public via open-access publication.
: Not applicable
: TM received Nanoseal and CAREDYNE Shield from GC for this study, but the authors have not received any financial support. Any competing interests will be managed by the Conflict of Interest Committee of Nagasaki University Hospital.