Sterne, Jonathan A. C. http://orcid.org/0000-0001-8496-6053
Diaz, Janet
Villar, Jesús
Murthy, Srinivas
Slutsky, Arthur S.
Perner, Anders
Jüni, Peter
Angus, Derek C.
Annane, Djillali
Azevedo, Luciano Cesar Pontes
Du, Bin
Dequin, Pierre-Francois
Gordon, Anthony C.
Green, Cameron
Higgins, Julian P. T.
Horby, Peter
Landray, Martin J.
Lapadula, Giuseppe
Le Gouge, Amelie
Leclerc, Marie
Savović, Jelena
Tomazini, Bruno
Venkatesh, Balasubramanian
Webb, Steve
Marshall, John C.
,
Article History
Received: 11 July 2020
Accepted: 29 July 2020
First Online: 24 August 2020
Ethics approval and consent to participate
: All trials received ethics approval. No ethics approval was required for this secondary data analysis.
: Not applicable
: Jonathan A C Sterne is partly funded by the NIHR Bristol Biomedical Research Centre. Jesus Villar received a Research grant from MAQUET (Sörna, Sweden) to perform a clinical trial on mechanical ventilation. Srinivas Murthy is a member of the REMAP-CAP International Trial Steering Committee. Arthur Slutsky is co-PI of the Dexamethasone in COVID ARDS study and is supported by grants from the Canadian Institutes of Health Research (CIHR). Anders Perner is the sponsor-investigator of the COVID STEROID trial, which is funded by the Novo Nordisk Foundation and supported by Pfizer. Peter Jüni serves as unpaid member of steering groups or executive committees of trials funded by Abbott Vascular, Astra Zeneca, Biotronik, Biosensors, St. Jude Medical, Terumo and The Medicines Company, has received research grants to the institution from Appili Therapeutics, Astra Zeneca, Biotronik, Biosensors International, Eli Lilly, The Medicines Company, and honoraria to the institution for participation in advisory boards and/or consulting from Amgen, Ava and Fresenius, but has not received personal payments by any pharmaceutical company or device manufacturer. Derek C Angus is a member of the REMAP-CAP International Trial Steering Committee and chair of the REMAP-CAP Corticosteroid Domain-specific Working Group. Djillali Annane has been involved as an investigator and in the steering committee for CAPE-COVID that was publicly funded by a grant from the French Ministry of Health; as an investigator, chief investigator for France, and member of the Steering committee for REMAP-CAP, he received a grant from the French Ministry of health to support French sites that participated to REMAP-CAP corticosteroids domain. He has not received any personal payment from any private or public entities. Luciano C P Azevedo is the PI for the Codex trial, which received donation of dexamethasone from Aché Pharmaceuticals. Bin Du is the PI for the corticosteroids therapy in adult patients with COVID-19 and ARDS (Steroids-SARI) trial, which was funded by a grant from the Ministry of Science and Technology; and has received research grants from Chinese Academy of Medical Sciences (Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS) [2016-I2 M-1-014 and 2019-I2M-1-001]). Pierre Francois-Dequin is the principal investigator of the CAPE COVID trial which was funded by a program of the French Ministry of Health. Anthony C Gordon is the UK Chief Investigator and a member of the REMAP-CAP International Trial Steering Committee, is funded by an NIHR Research Professorship (RP-2015-06-18) and is supported by the NIHR Imperial Biomedical Research Centre. Outside of this work he has received consulting fees from GlaxoSmithKline and Bristol Myers Squibb paid to his institution. Cameron Green is a member of the REMAP-CAP International Trial Steering Committee. Julian P T Higgins is partly funded by the NIHR Bristol Biomedical Research Centre and partly funded by the NIHR Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol and Weston NHS Foundation Trust. Peter Horby is co-chief investigator of the RECOVERY trial of potential treatments for COVID-19 (funded by UKRI and NIHR). He is an employee of the University of Oxford with salary supported by the Wellcome Trust, National Institute of Health Research, and the Medical Research Council. Martin Landray is co-chief investigator of the RECOVERY trial of potential treatments for COVID-19 (funded by UKRI and NIHR), research funding to University of Oxford received from Novartis, Boehringer Ingelheim, and Merck Sharp & Dohme, infrastructure and core funding received from Health Data Research UK, NIHR Oxford Biomedical Research Centre, UK Biobank Ltd, MRC Population Health Research Unit, and British Heart Foundation Centre for Research Excellence. He is an employee of University of Oxford with salary supported by Li Ka Shing Foundation, Health Data Research UK, NIHR Oxford Biomedical Research Centre, Wellcome Trust, and National Health Service. Jelena Savović is partly funded by the NIHR Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol and Weston NHS Foundation Trust. Balasubramanian Venkatesh is a member of the trial management committee of the COVID STEROID trial. Steve Webb is supported by St John of God Healthcare and this work was supported by grants from National Health and Medical Research Council (Australia), Minderoo Foundation, Health Research Council of New Zealand. John Marshall reports honoraria from AM Pharma (DSMB Steering Committee Chair), receives funding from CIHR, is the Canadian PI for REMAP-CAP, is a member of the REMAP-CAP International Trial Steering Committee, and is co-chair of the WHO Working Group on Clinical Characterization and Management. The other authors report no conflicts of interest.