Received: 12 August 2020
Accepted: 14 August 2020
First Online: 7 September 2020
Ethics approval and consent to participate
: This trial has been approved on 18<sup>th</sup> June 2020 by HMC-IRB under the trial number MRC-05-082.I declare this IRB acts fully independent as an ethical committee and adheres to local law, GCP and the Helsinki Declaration.All participants are consented personally. If the participant is not able to give consent them self their legal representative is eligible to consent. If this person is not available a deferred consent is taken, which needs later confirmation by the participant or their legal representative.
: Not applicable
: The authors declare that they have no competing interests.