Funding for this research was provided by:
Received: 18 February 2021
Accepted: 18 February 2021
First Online: 8 March 2021
Ethics approval and consent to participate
: The FLARE trial has ethical approval from Wales REC 3, REC reference 20/WA/0210, dated 16<sup>th</sup> July 2020. The most recent amendment, #4, was approved 1<sup>st</sup> February 2021.We certify that this trial has received ethical approval from the appropriate ethical committee as described above. Written informed consent to enter and be randomised into the trial will be obtained from participants, after explanation of the aims, methods, benefits and potential hazards of the trial.
: Not applicable.
: The authors declare that they have no competing interests.