Funding for this research was provided by:
Grantová Agentura České Republiky (GBP505/12/G112, P506/12/1258)
Univerzita Karlova v Praze (SVV 244-260432/2017, PROGRES Q43, UNCE 204017)
Masarykova Univerzita (MUNI/A/1362/2016)
Ministerstvo Školství, Mládeže a Tělovýchovy (InterBioMed LO1302, CZ.02.1.01/0.0/0.0/16_019/0000759)
Akademie Věd České Republiky (RVO 61388963)
Received: 14 September 2017
Accepted: 22 January 2018
First Online: 6 March 2018
Ethics approval and consent to participate
: The maintenance and care of experimental animals was carried out in accordance with European Directive 2010/63/EU, and according to Czech law (246/1992 and 359/2012) for biomedical research involving animals. Experiments were performed with a legal consent of the relevant institutional animal research ethics committees, namely the Professional Ethics Committee of the Faculty of Science, Charles University in Prague and the Branch for Research and Development of the Ministry of Education, Youth and Sports of the Czech Republic. The animal facility, its equipment, animal welfare and accompanying services, including maintenance of experimental animals, have been approved by the Branch of Animal Commodities of the Ministry of Agriculture of the Czech Republic (approval no. 13060/2014-MZE-17214).
: Not applicable.
: The authors declare that they have no competing interests.
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