Funding for this research was provided by:
Received: 3 April 2019
Accepted: 28 August 2019
First Online: 6 September 2019
Ethics approval and consent to participate
: Studies 1–3 were conducted in accordance with United States Food and Drug Administration Good Laboratory Practice regulations for nonclinical studies and with applicable target animal safety guidelines (FDA Guidance for Industry #185 (study 1) or #33 (studies 2 and 3). Studies 4 and 5 were conducted in compliance with VICH GL9. All <i>in vivo</i> work was completed after ethical review and in full compliance with applicable local, state, national, and international animal welfare regulations.
: Not applicable.
: MJK, SM, AF, WC, TLW, KE, LL, TM, KA, EM, SN, KK, RC and JFB are current or former employees of Zoetis.