Funding for this research was provided by:
Astellas Foundation for Research on Metabolic Disorders
Japan Society for the Promotion of Science (KAKENHI Grant Number 17H05012, KAKENHI Grant Number 26292189, KAKENHI Grant Number 19H03134)
Received: 17 September 2019
Accepted: 30 December 2019
First Online: 14 January 2020
Ethics approval and consent to participate
: Animal experiments were performed in a humane manner and approved by the Institutional Animal Experiment Committee of the University of Tsukuba. Experiments were conducted in accordance with the Regulation of Animal Experiments of the University of Tsukuba and the Fundamental Guidelines for Proper Conduct of Animal Experiments and Related Activities in Academic Research Institutions under the jurisdiction of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
: Not applicable.
: The authors declare that they have no competing interests.