Funding for this research was provided by:
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Spinoza grant, 918-15-667)
European Research Council (310372)
H2020 European Research Council (779257)
Text and Data Mining valid from 2019-06-17
Received: 10 January 2019
Accepted: 17 May 2019
First Online: 17 June 2019
Ethics approval and consent to participate
: Patients/families were counseled and provided informed consent in the realm of the diagnostic procedure, written informed consent was obtained from all patients, and our research project was approved by the local ethics committee (Commissie Mensgebonden Onderzoek Regio Arnhem- Nijmegen). All participants provided written informed consent to participate in the study. Families were counseled and provided consent for “PID gene panel only” or “gene panel and exome-wide analysis” as presented here. The research conforms to the principles of the Declaration of Helsinki.
: All individuals involved in this study provided consent for publication. We also obtained consent to publish the clinical information of all individuals presented in this study.
: The authors declare that they have no competing interests.