Funding for this research was provided by:
Scottish Funding Council (HR03006)
Australian Research Council (DP160102400)
Australian National Health and Medical Research Council (1078037, 1078901, 1103418, 1107258, 1127440 and 1113400)
Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6)
Medical Research Council UK and the Wellcome Trust (104036/Z/14/Z)
Alzheimer’s Research UK Major Project Grant (RUK-PG2017B-10)
Text and Data Mining valid from 2019-08-23
Received: 9 May 2019
Accepted: 16 August 2019
First Online: 23 August 2019
Ethics approval and consent to participate
: Following written informed consent, venesected whole blood was collected for DNA extraction in both LBC1921 and LBC1936. Ethics permission for the LBC1921 was obtained from the Lothian Research Ethics Committee (wave 1 LREC/1998/4/183). Ethics permission for the LBC1936 was obtained from the Multi-Centre Research Ethics Committee for Scotland (wave 1 MREC/01/0/56), the Lothian Research Ethics Committee (wave 1 LREC/2003/2/29), and the Scotland A Research Ethics Committee (waves 2 and 3 07/MRE00/58). Research was carried out in compliance with the Declaration of Helsinki.All donated blood and information in SGPD were collected in accordance with the National Health and Medical Research Council’s National Statement on Ethical Conduct in Human Research, with written consent obtained from each participant. Ethical approval for the SGPD was obtained from the Human Research Ethics Committee (HREC) at Griffith University (Protocol No: ESK/04/11/HREC).All components of GS received ethical approval from the NHS Tayside Committee on Medical Research Ethics (REC Reference Number: 05/S1401/89). GS has also been granted Research Tissue Bank status by the Tayside Committee on Medical Research Ethics (REC Reference Number: 10/S1402/20), providing generic ethical approval for a wide range of uses within medical research.
: Not applicable.
: The authors declare that they have no competing interests.