Funding for this research was provided by:
National Institute for Health Research (NIHR HPRU)
U.S. Food and Drug Administration
Received: 27 November 2019
Accepted: 12 November 2020
First Online: 11 January 2021
Ethics approval and consent to participate
: This study was reviewed by the National Research Ethics Committee, part of the National Health Service, UK. A North-Westsub-committee considered the ethical aspects of this study and approved this work under REC reference 15/NW/0744. The patient provided informed consent to this work after discussions with NHS medical staff. This study was conducted in accordance with the declaration of Helsinki. All work was performed in accordance with the Human Tissue Act (2004). The study is listed on the Health Research Authority website, and can be found under IRAS 189909.The patient received all experimental treatments under compassionate use: approval was obtained through an established internal clinical review and governance process, and included fully informed patient consent.
: Written informed consent was obtained from the patient to publish data from this study and reviewed under REC reference 15/NW/0744.
: The authors declare that they have no competing interest.