Funding for this research was provided by:
Stockholms Läns Landsting (20190466, 20190989, 20170022)
Vetenskapsrådet (2017-02936, 2019-02078, 2019-01154)
Knut och Alice Wallenbergs Stiftelse (KAW 2014.0293)
Norges Forskningsråd (the BIGMED grant)
Received: 29 June 2020
Accepted: 11 February 2021
First Online: 17 March 2021
Ethics approval and consent to participate
: Ethics approval was given by the Regional Ethical Review Board in Stockholm, Sweden (ethics permit numbers 2008-351-31, 2012/2106-31/4, 2012/222-31/3, 2014/995-32, and 2015/416-31). This ethics permit allows for use of clinical samples for analysis of scientific importance as part of clinical development, and for lifting clinical filters to interrogate the whole genome in selected cases. Our IRB approval does not require us to get written consent for clinical testing. The research conformed to the principles of the Helsinki Declaration.
: Not applicable
: The authors declare that they have no competing interests.