Funding for this research was provided by:
National Natural Science Foundation of China (81801197, 81870954, 81825008, 82090043)
Received: 13 February 2020
Accepted: 4 March 2021
First Online: 26 March 2021
: Postmortem formalin-fixed brain sections were obtained from the Department of Pathology of Ohio State University (Columbus, OH) and the Brain and Body Donation program of Banner Sun Health Research Institute (Sun City, AZ). Each group included two men and two women. All patients, or their next of kin, in these tissue donation programs gave written informed consent for brain autopsy and the use of brain tissues for research purposes. The study protocols for brain tissue acquisition were approved by the Institutional Review Boards of Ohio State University and Banner Sun Health Research Institute. The study protocols using these specimens were approved by the Institutional Review Boards of Xuanwu Hospital and Tianjin Medical University General Hospital. The human research in this study conformed to the principles of the Helsinki Declaration. All animal experimental protocols were performed in compliance with the ARRIVE guidelines and were approved by the Institutional Animal Care and Use Committee of Xuanwu Hospital and Tianjin Medical University General Hospital.
: Patients consented for the publication of data in the tissue donation program.
: The authors declare that they have no competing interests.