Funding for this research was provided by:
BC Children’s Hospital Foundation
Genome British Columbia
Canadian Institutes of Health Research (CIHR – SCA-145104)
Michael Smith Foundation for Health Research
Rare Disease Foundation (2332)
Received: 3 September 2020
Accepted: 5 July 2021
First Online: 9 August 2021
Change Date: 13 September 2021
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1186/S13073-021-00961-4
: The clinical next-generation sequencing datasets used in this study are from patients and their biological parents recruited for the CAUSES or IMAGINE Study. Written informed consent was obtained from all CAUSES and IMAGINE Study participants, and both Studies were approved by the Institutional Review Board of the Children’s and Women’s Health Centre of British Columbia and the University of British Columbia (H15-00092 and H16-02126, respectively). The research in this study conforms to the principles of the Helsinki Declaration.
: Not applicable
: ED and MAE are employees of Illumina, Inc., a public company that develops and markets systems for genetic analysis. The remaining authors declare that they have no competing interests.