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Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Crossref DOI link: https://doi.org/10.1186/s13075-018-1552-9

Published Online: 2018-03-22

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Suzuki, Kohjin

Yoshida, Kohsuke

Ueha, Takeshi

Kaneshiro, Kenta

Nakai, Ayako

Hashimoto, Naonori

Uchida, Koto

Hashimoto, Teppei

Kawasaki, Yoshiko

Shibanuma, Nao

Nakagawa, Natsuko

Sakai, Yoshitada

Hashiramoto, Akira
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Article History

Received: 25 September 2017

Accepted: 25 February 2018

First Online: 22 March 2018

Ethics approval and consent to participate

: This study has been approved by the ethics committee of Kobe University Graduate School of Health Sciences (#579–1) and Kobe Kaisei Hospital (#0072), in accordance with the Declaration of Helsinki. Written informed consent was obtained from each patient before study enrolment.

: Not applicable.

: The authors declare that they have no competing interests.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.