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Article History

Received: 30 December 2017

Accepted: 28 March 2018

First Online: 2 May 2018

Ethics approval and consent to participate

: The study was approved by the ethics committee of Paris 7 university. Patients received a written information sheet with details on the study. All gave informed consent before any study procedure. A subset of patients agreed to sign a specific informed consent for LC-MS measurement.

: AA, AP, and GH are employees of AstraZeneca, and JNM was an employee of Ardea Biosciences, a wholly owned subsidiary of AstraZeneca at the time of this work. The other authors declare that they have no competing interests.

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