Funding for this research was provided by:
Japan Agency for Medical Research and Development (H26-Choju-Ippan-001, 15dk0107007h0003, 16dk0110007h0003)
Received: 2 October 2018
Accepted: 1 April 2019
First Online: 15 April 2019
Ethics approval and consent to participate
: All participants provided written informed consent for participation in this study. This study was designed in accordance with the Helsinki declaration and was approved by the ethics committee of Kyoto University Graduate School and Faculty of Medicine (No.C278).
: Not applicable.
: HI has received a research grant and/or speaker fee from Bristol-Myers Squibb, Astellas, and Asahi-Kasei. SM has received a research grant and/or speaker fee from Kyocera, Zimmer-Biomet and Smith&Nephew. ST, YT, TN, MF, TK, MA, KS, TK, and FM declare that they have no competing interests. The sponsors were not involved in the study design; in the collection, analysis, interpretation of data; in the writing of this manuscript; or in the decision to submit the article for publication. The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the subject of this article.
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