Funding for this research was provided by:
Ironwood Pharmaceuticals, Incorporated (ESR-15-11Q77)
Received: 18 February 2019
Accepted: 14 June 2019
First Online: 29 June 2019
Ethics approval and consent to participate
: The trial was approved by the Institutional Review Boards at the two academic medical centers conducting this study, University of Alabama at Birmingham (UAB) and at the University of Nebraska Medical Center (UNMC, Omaha, NE).
: Not applicable.
: T. Mikuls had a research support from Ironwood/Astra Zeneca and Horizon. K. Saag had a research support from Ironwood, Horizon, Takeda, and Sobi and is a consultant at Horizon, Sobi, Shanton, and Takeda. The other authors declare that they have no competing interests.