Funding for this research was provided by:
Ironwood Pharmaceuticals, Incorporated
Received: 7 February 2020
Accepted: 20 July 2020
First Online: 3 August 2020
Ethics approval and consent to participate
: The trial was approved by the Institutional Review Boards at the two academic medical centers conducting this study, University of Alabama at Birmingham (UAB) and the University of Nebraska Medical Center (UNMC, Omaha, NE).
: Not applicable.
: T. Mikuls: research support—Ironwood/Astra Zeneca, Horizon.K. Saag: research support—Horizon, Takeda; consulting—Horizon, Kowa, LG Chem, Takeda.Others: none.