Funding for this research was provided by:
Japan Society for the Promotion of Science (19H03549, 16K09695)
Japan Agency for Medical Research and Development (19dk0310099)
Received: 19 November 2019
Accepted: 12 February 2020
First Online: 21 February 2020
Ethics approval and consent to participate
: All subjects provided written, informed consent to participate in this study. Ethical approval was granted by the Ethics Committees of Nagasaki Kawatana Medical Center (approval number 2011-21) and the Nagasaki University Graduate School of Biomedical Sciences (approval number 11032820).
: The authors declare that they have no competing interests.