Received: 11 November 2021
Accepted: 18 March 2022
First Online: 25 April 2022
: Ethical approval to perform genetic association studies in NOAR - REC Ref 2003/075, 18 December 2003, Norwich Local Research Committee (NHS).
: All authors have completed the Unified Competing Interest Form (available on request from the corresponding author) and declare no support from any organisation for the submitted work, no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work. Dr. Barton reported receiving speaker fees from Roche Chugai and grant support from BMS. Dr. Bowes reported a project grant from BHF.