Funding for this research was provided by:
National Institute of Health Research (RP-PG-0610–10,066)
the National Institute of Health Research (NIHR) Advanced Research Fellowship Award (NIHR300826)
Received: 6 February 2022
Accepted: 9 August 2022
First Online: 10 September 2022
: All six studies have been described in detail previously: they were all approved by Research Ethics Committees and all participating patients gave written informed consent.<i>CARDERA</i> was approved by the South East Multicentre Research Ethics Committee (MREC (1) 99/04). It was registered as ISRCTN 32484878.CARDERA-2 was approved by the South East Research Ethics Committee (REC reference number MREC 02/1/089). It was registered at ISRCTN 15819795.TACIT was approved by University College London Hospital Research Ethics Committee (MREC Ref 07/Q0505/57). It was registered as ISRCTN 37438295.TITRATE was approved by the London – West London & GTAC National Research Ethics Service Committee (REC Ref 13/LO1308). It was registered as ISRCTN 70160382OPTTIRA was approved by the North West London Research Ethics Committee (REC Ref 10/H0720/69). It was registered as ISRCTN 28955701REMIRA was approved by the Wandsworth Research Ethics Committee (Reference 09/H0803/154).
: Not relevant.
: The authors declare that they have no competing interests.