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Article History

Received: 14 January 2022

Accepted: 3 September 2022

First Online: 16 September 2022

Declarations

:

: The study protocol was approved by the Ethics Review Committee of the University of Occupational and Environmental Health, Japan, and written informed consent was obtained from all participants at the time of sample collection (H24-30). All animal experiments were approved by the Ethics Committee of Animal Care and Experimentation of the University of Occupational and Environmental Health, Japan, in accordance with the Guiding of Principle for Animal Care Experimentation (AE 14-025).

: Not applicable.

: Mitsubishi Tanabe Pharma Corporation provided support in the form of salaries for K. Sakata. K. Nakano has received speaking fees from Astellas, UCB, Mitsubishi-Tanabe, Eisai and has received research grants from Mitsubishi-Tanabe, Eisai, and Eli Lilly. K. Ohmura has received speaking fees and/or honoraria from Abbvie, Actelion, Astellas, Ayumi, Asahikasei-Pharma, Bristol-Myers, Eisai, Eli Lilly, GSK, Janssen, Mitsubishi Tanabe, Novartis, Sanofi and has received research grants from Bristol-Myers, Eisai, Eli Lilly, GSK, Mitsubishi-Tanabe, Nippon-Kayaku. S. Nakayamada has received speaking fees from Bristol-Myers, Sanofi, Abbvie, Eisai, Chugai, Pfizer, Takeda, Asahi-kasei and has received research grants from Mitsubishi-Tanabe, Novartis and MSD. Y. Tanaka has received speaking fees and/or honoraria from Daiichi-Sankyo, Astellas, Chugai, Eli Lilly, Pfizer, Abbvie, YL Biologics, Bristol-Myers, Takeda, Mitsubishi-Tanabe, Novartis, Eisai, Janssen, Teijin and has received research grants from Asahi-kasei, Mitsubishi-Tanabe, Chugai, Takeda, Sanofi, Bristol-Myers, UCB, Daiichi-Sankyo, Eisai and Ono. All other authors declare no conflict of interest.