Received: 16 January 2019
Accepted: 5 June 2019
First Online: 10 June 2019
Ethics approval and consent to participate
: Written informed consent was obtained for all patients included in CENTAURO and CENTAURO-2 clinical trials. Both clinical trials were conducted in accordance with the ethical guidelines of the Declaration of Helsinki and approved by the following institutions: Cuban Regulatory Authority (CECMED), and the Clinical Ethics Committee of the Center of Medical and Surgical Research, Havana; Celestino Hernández Robau Hospital, Santa Clara; and José Ramón López Tabranes Hospital, Matanzas.
: Not applicable.
: One author declares a financial competing interest. MBR is the inventor on a patent application submitted by the Center for Genetic Engineering and Biotechnology that covers the use of the vaccine.