Received: 16 May 2019
Accepted: 13 June 2019
First Online: 18 June 2019
Ethics approval and consent to participate
: Animal experimental procedures in this study were in compliant with the regulations of Animal Welfare Committee in Novartis Institutes for BioMedical Research Tsukuba.
: Not applicable.
: All authors are or were employees of Novartis Pharma at the time of the work was carried out.