Funding for this research was provided by:
National Institutes of Health (R01CA158112, P50CA100632)
F. M. Kirby Foundation (American Cancer Society Clinical Research professor)
Received: 27 March 2019
Accepted: 12 July 2019
First Online: 22 July 2019
Ethics approval and consent to participate
: The study protocol was approved by each institutional review boards at every participating site and was conducted in accordance with the Declaration of Helsinki, Good Clinical Practice, and all local and federal regulatory guidelines. A parent or legal guardian provided written informed consent, with patient assent as appropriate according to institutional requirements.
: Not applicable
: XYS and MA are employees of Astex Pharmaceuticals. GJR and J-PJI received consulting fees from an advisory committee, and J-PJI received research funding from Astex Pharmaceuticals. WC, ADK, PK, HF, JJ, and HMK declare that they have no competing interests.