Funding for this research was provided by:
Economic and Social Research Council (ES/N000498/1)
Biotechnology and Biological Sciences Research Council (ES/N000498/1)
Medical Research Council (G0902144)
Medical Research Council (MC_UU_00011/1, MC_UU_00011/5)
Programme Grants for Applied Research (RP-PG-0707-10034)
Received: 24 May 2019
Accepted: 23 September 2019
First Online: 27 November 2019
Ethics approval and consent to participate
: Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees (ExternalRef removed). Informed consent for the use of data collected via questionnaires and clinics was obtained from participants following the recommendations of the ALSPAC Ethics and Law Committee at the time. Consent for biological samples has been collected in accordance with the Human Tissue Act (2004) (ref: B2818).Full ethical approval for the HN5000 clinical cohort study was granted by the South West Frenchay Regional Ethics Committee (ref: 10/H0107/57).
: Not applicable
: The authors declare that they have no competing interests.