Received: 9 November 2017
Accepted: 22 January 2018
First Online: 20 February 2018
Ethics approval and consent to participate
: The study was approved by the local medical ethics committee. All patients provided written informed consent for their clinical data to be used for research purposes.
: Not applicable.
: CET is a member of the Innogenetics International Advisory Boards of Fujirebio/Innogenetics and Roche. FB serves/has served on the advisory boards of Bayer-Schering Pharma, Sanofi-Aventis, Biogen-Idec, Teva Pharmaceutical Industries, Merck-Serono, Novartis, Roche, Synthon BV, Jansen Research, and Genzyme. FB has received funding from the Dutch MS Society and the European Union Seventh Framework Program (EU-FP7) and has been a speaker at symposia organized by the Serono Symposia Foundation and Medscape. PS has served as a consultant for Wyeth-Elan, Genentech, Danone, and Novartis and has received funding for travel from Pfizer, Elan, Janssen, and Danone Research. JL reports that Combinostics Oy owns the following intellectual property rights related to this paper: (1) J. Koikkalainen and J. Lotjonen. Method for inferring the state of a system. Publication number US 7840510 B2; application number PCT/FI2007/050277; (2) J. Lotjonen, J. Koikkalainen, and J. Mattila. State inference in a heterogeneous system. Application number PCT/FI2010/050545; FI20125177. JL is a shareholder in Combinostics Oy. WMvdF performs contract research for Boehringer Ingelheim. Research programs of WMvdF have been funded by ZonMw, the Netherlands Organization for Scientific Research (now), EU-FP7, Alzheimer Nederland, Cardiovascular Onderzoek Nederland, Stichting Dioraphte, Gieskes-Strijbis Fonds, Boehringer Ingelheim, Piramal Neuroimaging, Roche BV, and Janssen Stellar. All funding is paid to WMvdF’s institution. The other authors declare that they have no competing interests.
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