Funding for this research was provided by:
National Institute of General Medical Sciences (P20GM109025)
National Institute of Neurological Disorders and Stroke (U01NS093334)
National Institute on Aging (R01AG053798, P20AG068053, R35AG71476)
Received: 26 April 2021
Accepted: 29 April 2021
First Online: 10 May 2021
: Not applicable.
: Not applicable.
: PA has received research funding from NIA, FNIH, the Alzheimer’s Association, Janssen, Lilly, and Eisai and personal fees from Biogen, Merck, Roche, Abbvie, ImmunoBrain Checkpoint, Rainbow Medical, and Shionogi. CL has provided consultation to Acumen Pharmaceutical, Apellis Pharmaceutical, Biogen (ADvance Medical Education International Working Group), Cambridge Healthcare Research, and Cognition Therapeutics. She received in-kind research support from Vivoryon Therapeutics. JC has provided consultation to Acadia, Alkahest, AriBio, Avanir, Axsome, Behren Therapeutics, Biogen, Cassava, Cerecin, Cerevel, Cortexyme, EIP Pharma, Eisai, GemVax, Genentech, Green Valley, Grifols, Janssen, Jazz, Karuna, Merck, Novo Nordisk, Otsuka, ReMYND, Resverlogix, Roche, Signant Health, Sunovion, Suven, United Neuroscience, and Unlearn AI pharmaceutical and assessment companies. Dr. Cummings has stock options in ADAMAS, AnnovisBio, MedAvante, BiOasis, and United Neuroscience. Dr. Cummings owns the copyright of the Neuropsychiatric Inventory. Dr Cummings has the following research support: NIGMS P20GM109025; NINDS U01NS093334; NIA R01AG053798; NIA P20AG068053; NIA R35AG71476. AA has received honoraria for consulting; participating in independent data safety monitoring boards; providing educational lectures, programs, and materials; or serving on advisory boards for AbbVie, Acadia, Allergan, the Alzheimer’s Association, Axovant, AZ Therapies, Biogen, Grifols, Harvard Medical School Graduate Continuing Education, JOMDD, Lundbeck, Merck, Roche/Genentech, Novo Nordisk, Sunovion, and Suven. MS has provided consultation to Alzheon, Biogen, Cortexyme, Roche-Genentech, Stage 2 Innovations/Renew Research, Acadia, T3D, Eisai, and KeifeRx. He is on the Speaker’s Bureau for Health and Wellness Partners. He holds stock/options in rain Health Inc, NeuroTau, Optimal Cognitive Health Company, uMethod Health, Versanum, Athira, and Cognoptix. SS was a site PI and co-chair of the investigator steering committee for the ENGAGE trial, and he receives research support and consultancy fees from Lilly, Biogen, Avid, Eisai, Genentech, and Roche.