Funding for this research was provided by:
National Institutes of Health (R01AI091905, R01AI121226, R01 HL082925)
Asthma UK (364)
Received: 10 April 2021
Accepted: 2 July 2021
First Online: 23 July 2021
: Isle of Wight Local Research Ethics Committee approved 10 years assessment as well as collection of blood for genetic studies into asthma and allergy (No. 18/98, dated 07/20/1998). For the 18-year follow-up, ethical approval was given by the Isle of Wight, Portsmouth and SE Hampshire Local Research Ethics Committee (No. 06/Q1701/34, dated 06/16/2006). The Internal Review Board (IRB) at the University of Memphis (FWA00006815, IRB ID: #3917) gave approval for data analysis at University of Memphis. Written informed consent was obtained from parents during in-person visits. For participants assessed by phone interview, consent was documented on the consent form with the name of the person giving consent, and the name and signature of the person taking the form were recorded. For ALSPAC, ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees and consent for collection of biological samples was provided in accordance with the Human Tissue Act (2004). For age seven years, United Bristol Healthcare Trust: E4168 (ALSPAC Hands on Assessments at Age Seven), Southmead Health Services: 67/98 (Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC)—Hands on Assessments at Age Seven) and Frenchay Healthcare Trust: 98/52 (Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC). Hands on Assessments at Age Seven). For age 15 years, Central & South Bristol Research Ethics Committee (UBHT): 06/Q2006/53 Avon Longitudinal Study of Parents and Children (ALSPAC), Hands on Assessments: Teen Focus 3 (Focus 15 +), and for age 17 years, North Somerset & South Bristol Research Ethics Committee: 08/H0106/9 Avon Longitudinal Study of Parents and Children (ALSPAC), Hands on Assessments: Teen Focus 4 (Focus 17 +). Full details of ethical approvals (local committees and approval numbers) are available at ExternalRef removed
: Not applicable.
: The authors declare that they have no competing interests.